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Enrichment was evaluated by a single-tailed Fishers exact test adjusted by the FDR

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NMERO DE REGISTRO SANITARIO: 26.023053/M

And similar, like no exercise or diet was part of this study

2017 Mar;17:57-66

Preliminary evidence further suggests MTHFR variants may modulate anti-TNF responses in an allele-dose manner, although results remain population-specific (128)