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They include: people who are under the legal drinking age, which is 21 in the United States pregnant women people who are recovering from alcohol use disorder people who are planning to drive, operate machinery, or participate in another activity that requires coordination and being alert people taking medications that can have a negative interaction with alcohol people with an underlying health condition that could be negatively affected by alcohol You should see a doctor if you think you or a loved one might be misusing alcohol

You could also consider a SAMe supplement, but bear in mind it is a medicine in some countries, and there is some evidence that it can imbalance the system and downregulate endogenous SAMe synthesis

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Mean insertion pain at the left tibia was 4.4 +/- 2.6, right tibia 3.6 +/- 2.3, and 3.0 +/- 1.5 for proximal humerus