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When cells face the challenge of oxidative stress, while being regulated by Nrf2, their own metabolic products (CO, Fe 2+ , biliverdin) can also form a positive feedback to enhance activity [93]

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Keap1 facilitates redox-sensitive regulation of kinase activation by serving as a scaffold for upstream MAPK regulators, including PGAM5, and Ikk Keap1s function as a substrate adapter for cullin-3 E3 ligase enables it to target MAPK pathway components for ubiquitination and destruction, whereas oxidative alteration of its cysteine residue can change these proteinprotein interactions [91]

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The derivatization procedure was optimized in order to achieve accurate quantification of TMA in clinical and food samples

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