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Estos mecanismos combinados contribuyen a la capacidad del pptido para estabilizar la microcirculacin y mitigar el estrs oxidativo, lo que respalda la investigacin en modelos de inflamacin crnica, proteccin orgnica y reparacin sistmica

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REFERENCES Neelakantan, H., et al

Moreover, KO mice for liver IGF-1 gene developed muscle insulin resistance (it is important to mention that skeletal muscle myocytes express high number of IGF-1R), showing an increase in insulin concentrations and a substantial decrease in the insulin-induced autophosphorylation of the insulin receptor and IRS in skeletal muscle (being normal in liver and white adipose tissue)