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Compared with the mean values of the control group, the FPN-treated group showed significant increments in the mean area percentages of GFAP-immunostained cells in both cerebral and cerebellar tissues (Fig

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When these isolated senescence cells were presented with FOXO4-DRI peptide, researchers reported that the peptide appeared to block FOXO4 proteins, allowing p53 to bind with DNA, which led to the nuclear exclusion of p53 and induction of apoptosis of the senescent Leydig cells