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It is well established that the intrinsic variation in the core microbiota composition across individuals (inter-individual variation) is important and it is therefore difficult to draw significant conclusions on studies investigating a limited number of participants 4,6

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Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, Damico D, Ropelle ER, Lutolf MP, Aebersold R (2016) NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice

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Groups with limited or no safety data Published human trials with AOD-9604 enrolled adults with obesity (BMI 30-45 kg/m^2), generally aged 18-65