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Studies of metabolism of As in microbes culminated in two comprehensive reviews of biological methylation by Frederick Challenger (Challenger, 1945, 1951) in which a pathway with steps leading from iAs to methylated products was proposed (Figure 1a)

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Increased expression and release of PTGS2 in the prostate is associated with ferroptosis, which promotes arachidonic acid metabolism and the release of inflammatory factors through the upregulation of PTGS2 [11]

Participants consumed 60 mL of GoChi twice daily for 30 days

Acetylcholinesterase inhibitors for diagnosed cognitive impairment, stimulant medications for ADHD under prescriber supervision, or lifestyle interventions (aerobic exercise, sleep optimization, dietary management) with robust clinical evidence