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Some individuals may have difficulty maintaining adequate B12 levels due to diet, stress, medications, or absorption issues

Frentzas S, Simoneau E, Bridgeman VL, Vermeulen PB, Foo S, et al

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found patterning signals like Shh expression were downregulated over time while expression of synthetic genes like TGF- and insulin growth factor (IGF) were upregulated in the same developmental window, providing insights into gene families required for patterning, ECM synthesis, and maintenance of the NP

Benjamini, Y., Drai, D., Elmer, G., Kafkafi, N

Above 50 M, it can activate MAPK pathways in certain cancer lines, requiring careful dosage control in oncology applications