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Materials and Methods For detailed methods, please see Text S1

Packer L, Rimbach G, Virgili F (1999) Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol

Half-life & zero-order kinetics : Phenytoins metabolism is saturable , resulting in zero-order kinetics (a fixed amount of the drug is cleared regardless of the drug level)

This work was supported by the National Natural Science Foundation of China (82370364, 82274071, 82300414, and 82170424), Jiangsu Province Excellent Youth Foundation (BK20240204), Jiangsu Natural Science Foundation (BK20231049, BE2020634 and BK20191138), Joint research project of the Chinese Society of Traditional Chinese Medicine, high-level introduction of talents and scientific research start-up funds of JNU (1286010241222100), the Fundamental Research Funds for the Central Universities (JUSRP124036), Medical Discipline Program of Wuxi Health Commission, the Science and Technology Projects of Wuxi City (M202207, BJ2023029), Clinical Research and Translational Medicine Research Program of Affiliated Hospital of Jiangnan University (LCYJ202306, LCYJ202226), Wuxi Science and Technology Development Fund Project Light of the Taihu Lake (K20221028), Wuxi Municipal Health Commission Youth Project (Q202226), Top Talent Support Program for young and middle-aged people of Wuxi Health Committee (HB2023045, BJ2023045, BJ2023029)

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