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Hepatic knockdown of GADD45 exacerbates steatohepatitis in MCD mice To investigate the role of hepatic GADD45 in steatohepatitis, C57BL/6J mice fed an MCD diet were injected with adenoviral shRNA targeting GADD45 via the tail vein, which effectively reduced hepatic GADD45 expression (Fig

10.1016/j.gene.2017.06.056 55 GanzT

Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinsons disease

CO (b) CH 2 -OCO-R 1 l-CH -O-CO-R ' (A19) (A16a) HO-D-R 3 (A18) (c) (b) l-CH 2 -OCO-0(CH 2 ) n R 2 (A20) (A16b) n = 0-2 Reagents: (a) CI-CH 2 -OS0 2 CI, aq