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Tranexamic acid (topical): Investigated in clinical trials for melasma with more robust evidence than IV glutathione

These parameters include animal species and strain, nutritional status, age and gender, as well as the use of appropriate control groups

This is illustrated by the termination of the BEACON (NCT01351675, Bardoxolone Methyl Evaluation in Patients with Advanced Chronic Kidney Disease and Type 2 Diabetes, 2011) and CARDINAL (NCT03019185, Patients with Alport Syndrome, 2017) trials due to cardiovascular safety concerns, despite achieving renal benefit-highlighting the imperative for rigorous long-term safety evaluation

Cell 165 , 14011415 (2016)

2011;7:539 Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJ

doi: 10.1016/j.immuni.2024.03.019 131 ChenYFangZMYiXWeiXJiangDS