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3.4 Cytokines and signal pathways Reduced cytokine synthesis, which inhibits T cell and macrophage activity, may be linked to the pathophysiology of CD

Mertens, et al

Oligodendrocytes appear to be particularly vulnerable to reactive oxygen species (ROS) and cytokines, such as tumor necrosis factor- (TNF), which induce cell death and prevent the differentiation of oligodendrocyte progenitor cells (OPCs)