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The -glucan, lentinan, is a bioactive compound produced by the macrofungus, Lentinus edodes, and has been found to have potential in improving the side effects of broad-spectrum antibiotic consumption

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309,315 Therapies targeting endothelial function are being explored to prevent or mitigate DPN progression (Fig

Preclinical toxicology studies in animals showed no concerning findings with chronic administration, but human long-term data would strengthen confidence in extended protocols

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AOD-9604 has weak efficacy data