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In September 2023, the FDA further restricted its use by classifying it as a Category 2 bulk drug, effectively barring its inclusion in compounded medications due to concerns about safety, impurities, and insufficient human data [37]

Non-pharmacological interventions include medication adjustment

Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release

Common factors that lead to black circles include: Pigmentation: Under-eye dark circles can be worsened by free radicals and other factors, including radiation, sun exposure, and pollution

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However, both forms have been used in fertility studies with positive results