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Dig Dis 32(3):186191 Pathak R, Asad M, Hrishikeshavan HJ, Prasad S (2007) Effect of peroxisome proliferator-activated receptor-alpha agonist (bezafibrate) on gastric secretion and gastric cytoprotection in rats

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The F(ab)' 2 may be reduced under mild conditions to break the disulfide linkage in the hinge region thereby converting the (Fab') 2 dimer into a Fab' monomer

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When pathogenic proteins directly compromise CMA components, thereby hindering their degradation capability, the toxic effects of CMA dysregulation may act as a primary etiological factor or as a secondary consequence when protein homeostasis is indirectly affected (172)