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Excessive ROS production by mitochondria, which directly damages lipids, proteins, and nucleic acids, is capable of triggering multiple pathological signaling pathways

[DOI] [PubMed] [Google Scholar] 98.Wang H., Li J., Wang Y., Gong X., Xu X., Wang J., Li Y., Sha X., Zhang Z

Inhibition of xCT or depletion of GSH results in GPX4 inactivation, leading to increased intracellular accumulation of lipid peroxides and promoting ferroptosis 13

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It is investigated in in-vitro cell culture systems for effects on fibroblast migration, endothelial cell tube formation, nitric oxide synthase (NOS) expression, and growth factor signaling pathways

Gliotoxin, another Candida mycotoxin, suppresses T-lymphocyte activity and promotes mast cell activation, contributing to histamine excess that drives anxiety and sleep disruption