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In biochemical and cellular research systems, DSIP has been examined for its involvement in neuroendocrine signalling, stress-associated pathways, and peptidereceptor interactions

Patients with reduced corneal nerve fiber density showed significant increases in nerve fiber density compared with no change in the placebo group

Recently, subpopulations of SST INs, including neuropeptide Y (NPY) SST-INs, have been implicated in cognitive resilience, with overrepresentation of this cell-type in human cortex linked to resilience against AD neuropathology 14