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206 Moreover, it was observed that erlotinib sensitivity in HCC4006 cells, which were cultured with TGF-, was restored upon withdrawal of TGF-

A phase I-IIa clinical trial in combination with carboplatin and paclitaxel investigated the effect of canfosfamide in advanced non-small cell lung cancer 114

Among all GPXs proteins, GPX4 has gained lot of attention these past last years for its essential role in inhibiting ferroptosis, a non-apoptotic and iron-dependent mode of regulated cell death [8, 9]

20%, P=0.18)

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However, the studies mentioned above highlight its significance in AS and offer new insights for investigating the pathological mechanisms of AS through ferroptosis