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PleiOTROPIC EFFects of GLP-1 and analogs on cell signaling, metabolism, and function

R.QuezadaV.BarriosA

These types of peptides are relatively common in the wellness and biohacker worlds, says Nadolsky

doi: 10.1016/j.pbi.2025.102705 26 ChenSGlawischnigEJrgensenKNaurPJrgensenBOlsenCEet al

Statistically significant reductions were observed compared to the placebo group at two specific sites: the right side of the face and the sun-exposed left forearm

Epithalon and Anti-Aging Cellular Effects In vitro studies on skin fibroblasts have investigated Epithalons potential impact on cell aging, proliferation, and extracellular matrix regulation.(5) Key reported effects: Decreased expression of MMP-9 , a matrix metalloproteinase that tends to increase with age Increased expression of Ki-67 and CD98hc , markers associated with cell proliferation and nutrient transport Inhibition of Caspase-3 , a central executioner protease in apoptosis These findings suggest that Epithalon may: Promote cellular regeneration and proliferation Suppress caspase-dependent apoptosis that rises during in vitro aging Support structural and functional maintenance of dermal cells 4