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Cells treated for 48 hours with bromelain at 25 g/mL, 50 g/mL, 100 g/mL, and 125 g/mL, showed a decrease in cell viability in a concentration-dependent manner ( Human breast cancer cells were frequently used to study the cytotoxic effects of different bioactive compounds ( +2 facilitating the entry into the cell ( 4.2 Apoptosis Apoptosis is a basic cell death mechanism, is vital in physiological processes, maintaining cellular homeostasis, and is detrimental in pathological processes, for example in tumour suppression (104)

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6B) or obvious signs of toxicity, such as loss of appetite, decreased activity, or lethargy