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S4: Hormone and Metabolic Modulators - Supplement Concerns Two substances found in some supplements and research chemicals were added to the prohibited list, and their presence raises serious safety concerns for both athletes and general consumers: BAM15 (1-(4-chloro-3,5-dinitrophenoxy)-2,4-dinitrobenzene) : A mitochondrial uncoupler that increases energy expenditure by disrupting normal cellular energy production

Fller M, Lang F

Mood Swings And Depression: People using isotretinoin for acne have reported drastic changes in mood

Pedro et al

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It has been extensively studied for its tissue-healing, anti-inflammatory, and cytoprotective properties across over 100 published research papers