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When this system becomes overwhelmed, cells, proteins, and DNA can suffer damage that accumulates over time

Metalloproteins containing cytochrome, iron-sulfur, or copper redox centers

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Chronic hyperglycemia impairs blood flow, reduces oxygen delivery, suppresses collagen and fibronectin synthesis, and diminishes immune cell function, collectively leading to delayed wound healing, prolonged inflammation, and increased risk of chronic infection 27,28

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Since fatigue implies over and/or misallocation of cellular energy on disease processes, studying metabolism can meaningfully identify aberrations in how cells use and produce energy