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Upon oxidative stress, sudden MPT causes massive ion influx that dissipates mitochondrial membrane potential and shuts down OXPHOS, ATP production and ROS overgeneration

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A systematic review of 63 studies confirmed that elevated GDF-15 is an independent predictor of all-cause and cardiovascular mortality, hospitalization, renal dysfunction, and major adverse cardiac events, mainly in patients with HF and atrial fibrillation (145)

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[DOI] [PubMed] [Google Scholar] [17].Conrad M, Moreno SG, Sinowatz F, et al