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Melatonin prevents Nrf2 degradation and augments its nuclear accumulation by inhibiting proteasomal [204]

Regardless of the mechanisms responsible for liver pathology, hepatic fibrosis is reversible with iron removal via phlebotomy therapy [47], with the risk of developing liver cancer significantly diminished if fibrosis staging is reduced to F2 or less [61]

In addition, Vitamin C is an excellent antioxidant for the immune system and overall cellular function

Table 8 Summary of microbiotaimmunemetabolic findings in BD

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