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All-cause admissions following a first ever exacerbation-related hospitalization in COPD

(1) ET capacity E of the decoupled electron transfer system ETS

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

Although this region of the enzyme has been confirmed to bind GSH and the C28-C31 pair has been observed to be necessary for the reduction of GSSG, there is no explicit evidence of how electrons are transmitted to the GR domain

The frequent onset of acute dose-dependent kidney injury, with the potential of leading to long-term renal damage, has limited its use and hampered adequate dosing regimens, increasing the risk of suboptimal plasma concentrations during treatment

Therefore, HDAC6-specific overexpression in AAV8-mediated gene delivery of LSECs may represent an innovative therapeutic strategy for ALD