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4.2 Potential impact of gut microbiota on ferroptosis in OA 4.2.1 Gut dysbiosis promotes lipid peroxidation and ferroptosis in OA In patients with OA, the significant dysregulation of the gut microbiota not only manifests as a disorder in the community structure but also profoundly affects the pathological process of OA by precisely regulating the key hub genes in the host lipid metabolism network

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Although existing studies indicate that MT has the potential to improve energy metabolism, reduce cell death, modulate inflammatory responses, and promote tissue regeneration, the specific molecular mechanisms and signaling pathways require further investigation