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28 An algorithm for the diagnosis of B 12 deficiency using these 3 biomarkers in addition to serum B 12 was presented by Hannibal et al

Most researchers who plan to reach the 12mg maintenance dose reconstitute with 2mL instead, which brings the injection volume down to a more manageable range

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According to the World Health Organization (WHO), the average onset age is between 15-35-years-old, with 75% of cases diagnosed before the age of 46