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However, the clinical development of these drugs has been hampered by a narrow therapeutic index and dose-limiting toxicities, including hyperlactatemia and neurotoxicity [111]

doi: 10.5530/pj.2015.6.16 153

34,35 The COX-1/2 enzymes and their metabolites are extensively involved in various cardiometabolic diseases via their potent capacity to control platelet aggregation, coagulation, vessel tone and permeability, pain reception, immune modulation, and adipogenesis