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The American Academy of Neurology (AAN) has a well-published guideline for treatment that includes gabapentinoids, anticonvulsants and antidepressants.6 Despite the availability of multiple pharmacologic therapies, many patients continue to have uncontrolled pain or cannot tolerate side effects

Laboratory Tests Patients with pernicious anemia have about three times the incidence of carcinoma of the stomach as the general population, so appropriate tests for this condition should be carried out when indicated

5-Amino-1MQ Animal Studies Studies using 5-Amino-1MQ specifically have demonstrated its potency and selectivity as an NNMT inhibitor, with IC50 values in the low micromolar range and good selectivity over other methyltransferases

Adults usually get 0.5 to 1 mL (500 to 1,000 mcg) weekly

Some benefit from monthly sessions, while others may need them more regularly

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