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An additional insult or pathogenic factor, often referred to in the literature as the second hit, is required to trigger the progression from simple steatosis to steatohepatitis (MASH), characterized by hepatocellular injury, inflammation, and varying degrees of fibrosis [32]

Several compounds were able to restore cell growth of CYS4 -OE cells on medium without methionine (Supplementary Table 4)

Red cell glycolytic enzyme disorders caused by mutations: an update

This inconsistency in efficacy assessment may stem from differences in disease stage, statin type, and treatment timing, highlighting the uncertainty regarding its clinical benefits