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Finally, because of the emerging role of pericytes in maintaining intra tumour vessels viable, targeting these cells has become the latest approach investigated to overcome resistance to anti VEGF treatment [67,68]

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Implementation of American Society of Clinical Oncology/College of American Pathologists HER2 Guideline Recommendations in a tertiary care facility increases HER2 immunohistochemistry and fluorescence in situ hybridization concordance and decreases the number of inconclusive cases