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Supplements work gradually, if at all, and effects are typically modest compared to prescription treatments

Nat Rev Mol Cell Biol 13:239250 Gariani K, Ryu D, Menzies KJ, Yi HS, Stein S, Zhang H, Perino A, Lemos V, Katsyuba E, Jha P, Vijgen S, Rubbia-Brandt L, Kim YK, Kim JT, Kim KS, Shong M, Schoonjans K, Auwerx J (2017) Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

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Subject age at the time of diagnosis ranged from 8 years to 14 years (11.4 2.1 years) in the topiramate group and 9 years to 15 years (12.6 1.8 years) in the propranolol group