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Another approach of TNF- pathway blockade that has been recently examined is the development of orally active small molecules (such as UCB-9260) that destabilize TNF- trimer, impeding TNF--TNFR1 binding and signaling [200]

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Serum concentrations of nitric oxide, tumor necrosis factor (TNF)- and TNF soluble receptors in women with overweight and obesity

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