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S1) and an increase in diastolic wall stress, which was statistically significant in DM_CKD as compared to WT only (Fig

117 SIRT1 also activates FOXO3a, which upregulates autophagy-related genes such as Atg5 and Atg7 , promoting autophagosome formation and reducing ROS levels, thereby attenuating inflammation

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Similarly, FMD involves periodic cycles of low-calorie, low-protein, and low-carbohydrate intake, mimicking the effects of fasting while providing essential nutrients (11)