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The data presented here suggest that Nle1-AngIV and Dihexa increase miniature synaptic activity by increasing dendritic spine densities and altering the morphological phenotype of postsynaptic spines in-vitro and may represent the mechanism that underlies facilitated learning observed AngIV analogues (Wright, Stubley et al

doi: 10.1038/s41586-023-06255-6 44 DollSFreitasFPShahRAldrovandiMDa SilvaMCIngoldIet al

Consult your doctor if you are pregnant or breastfeeding before using this medicine

IFN-responsive genes were hypomethylated to a greater extent in patients with renal involvement, and the authors highlighted the IFN regulatory factor family member gene IRF7, which was demethylated only in SLE patients with renal disease