human glutathione synthetase enzymes synthesis: A two-step pathway. Homeostasis of cellular Glutathione Metabolism and Its Implications

2022 May;45(5):941-961

Study of heavy metals pollution and vitellogenin levels in brown trout (Salmo trutta trutta) wild fish populations

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Mice with a deficiency of key components in the NF-B pathway die as a result of massive hepatocyte apoptosis induced by TNF 37,38 , supporting the critical role of maintenance of hepatocyte NF-B pathway in protecting against TNF cytotoxicity

Carion et al., TB-500 and Ciprofloxacin Adjunctive Therapy Improves Pseudomonas aeruginosa-Induced Keratitis, Cells, 7(10), 2018

It is therefore assumed that transcription from gdhA P2 serves to enhance gdhA expression when the concentration of -ketoglutarate is low, as during invasive disease, both to enhance the activity of the TCA cycle in the catabolic reaction, and to provide L-glutamate for glutathione biosynthesis in the anabolic reaction