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For the non-conjugation Phase II enzymes (quinone reductase and epoxide hydrolase), see the companion post on non-conjugation detox reactions

Reduction of class I GRXs is driven by glutathione, while GR maintains a highly reducing E GSH in the plastid stroma, re-reducing the generated GSSG

doi: 10.1080/13510002.2024.2333096 49 TsugawaS.NodaY.TarumiR.MimuraY.YoshidaK.IwataY.et al

Moreover, omega-3 PUFAs can enhance a cells endogenous antioxidant capabilities through multiple mechanisms: they can increase the activity of enzymes involved in antioxidant defense, such as glutathione peroxidase and superoxide dismutase, thus enhancing resistance to ROS-induced damage and reducing lipid peroxidation