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Methionine metabolism requires adequate thyroid function hypothyroid patients may show reduced lipotropic benefit until thyroid levels are optimised

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The prescribing information may be found here

56 OwenC

PubMed Chaudhuri RK, Bojanowski K

The Mayo Clinic notes that even at therapeutic mega-doses, side effects are uncommon and mild: headache, nausea, diarrhea, fatigue, and a tingling sensation in extremities