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The validation data align well with the literature [19] , indicating that the GST metabolic stability experimental protocol we established is feasible

Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases

16 It has been shown that influenza viruses induce oxidative stress mediated by an excess of ROS and a decrease of reduced glutathione, and that such conditions favour viral replication, with glutathione depletion pivotal for the folding and maturation of the viral glycoprotein and therefore viral replication

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Through a mechanism known as Hydrogen Transfer (HT), glutathione intercepts transient DNA radicals at astonishing speeds, preventing permanent DNA strand breaks or cross-linking from occurring before cell replication takes place