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In addition, the gene ontology (GO) analysis did not focus on canonical pathways of upstream regulators

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Interestingly, this inverse relationship between IGF-1 and longevity is not unique to humans

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Integrating mechanistic toxicity and fate data into formal LCA frameworks is the only way to conduct a true net environmental benefit analysis, accounting for impacts from precursor synthesis to end-of-life disposal.191,192 Informing fit-for-purpose regulation: current chemical regulatory frameworks like REACH are ill-equipped for the complexities of ENMs