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These coenzymes play key roles in glycolysis, pyruvate metabolism, protein and amino acid metabolism, pentose biosynthesis, glycerol metabolism, synthesis of high-energy phosphate bonds, and fatty acid metabolism

48,49 SIRT6 is also associated with redox status and inhibits cell aging and fibrosis

Selvarathinam et al

Demographics Known risk factors and demographics for neuropathic pains include female sex, younger age, higher BMI, smoking history, manual or personal service occupations, lower socioeconomic status, and ethnic minority status, along with medical conditions such as diabetes, peripheral neuropathy, musculoskeletal disorders (such as rheumatoid arthritis, osteoarthritis, and fibromyalgia)

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