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Proline at the third position is the key binding site of BPC157 for FBXO22 After confirming the critical role of FBXO22, we further investigated the interaction mechanism between BPC157 and FBXO22

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Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation

As previously noted, ROS activate the NFKB signalling pathway [17, 25]

doi: 10.1038/s44358-025-00030-3 281 MorelliK