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Methods: Suicide gene-meditated ablation of p16Ink4a-expressing senescent cells was carried out through intraperitoneal injection of AP20187 into young (8-week-old) or aging(20-month-old) INK-ATTAC mice at or age respectively

This highlights the significance of the peroxisome-ether-phospholipid axis in influencing the susceptibility of cells to ferroptosis, underscores the distinctive functional lipid class of PUFA-ePLs that undergoes dynamic regulation during cellular state transitions, and implies the existence of multiple regulatory nodes that can be targeted for therapeutic intervention in ovarian cancer