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We review astroglial pathophysiology across the spectrum of human CNS diseases and disorders, including neurotrauma, stroke, neuroinfection, autoimmune attack and epilepsy, as well as neurodevelopmental, neurodegenerative, metabolic and neuropsychiatric disorders

[DOI] [PMC free article] [PubMed] [Google Scholar] 111.DiLeo M.R., Hall R.E., Vellers H.L., Daniels C.L., Levitt D.E

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The longer effective tissue exposure is consistent with the actin-sequestration mechanism, which depends on intracellular accumulation rather than transient extracellular signaling

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