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As a mitigation strategy, if the test for period effect post unblinding was significant, then the statistical model for the primary outcome had to be recomputed only on the data from the first period of the trial (where period effect is taken out)as recommended by clinical practice (3537)

It remains to be seen whether properly conducted randomized clinical trials will strengthen or weaken these associations

This result not only enables us to determine how the CAR-HSC complex properly performs SC exfoliation after penetration in SC layers, but also implies that NMR can be a powerful tool for investigating interactions between molecules

Among the diverse array of contaminants, organic pollutantssuch as industrial dyes, pharmaceutical waste, contaminants of emerging concern (CECs), and harmful biological agentspose severe risks to ecosystems and human health 11,25

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