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Peptide therapeutics are not an exotic category that mainstream drug development cannot handle

in some type of cancers, CAT activity was lower in patients, especially in lymphomas, when compared with CAT activity in the normal population [62] and, in bipolar disorder, subjects with bipolar depression presented a significant increase in CAT levels [63]

MOTS-c No completed human efficacy trial of the native peptide

DOI: 10.3390/cancers15030910

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Methods/Design The systematic review protocol follows the recommendations of the Preferred Reporting Items for Systematic Review and Meta-analysis Protocol (PRISMA-P) [16], and to ensure the quality of the protocol, the PRISMA-P checklist was completed (S1 Checklist)