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To develop SPCD, a child must inherit two mutated SLC22A5 genes, one from each parent

A small study showed men with mild erectile dysfunction improved their erection hardness after one month of 1.5 grams daily of L-citrulline

Patients with Mitochondrial Disease: There is an increased risk of valproate-induced acute liver failure and resultant deaths in patients with hereditary neurometabolic syndromes caused by DNA mutations of the mitochondrial DNA Polymerase (POLG) gene (e.g., Alpers Huttenlocher Syndrome)