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Tsukasaki and Takayanagi, 2019)

Moreover, there is currently a lack of well-established biomarkers for ferroptosis, making it difficult to monitor in real time whether therapeutic agents have successfully activated ferroptosis pathways in clinical settings, which constitutes one of the major bottlenecks in clinical trial design (139)

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HHcy may also induce neuropathological changes, implicating it in the pathogenesis of neurodegenerative disorders (Cordaro et al