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G6PD mutation is more severe, and even the very young RBCs are depleted of the G6PD enzyme

In the presence of ongoing accumulation of A, a subset of microglia becomes abnormally activated, causing a neurotoxic effect that accelerates the progression of neurodegenerative diseases (100, 101)

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Cell Mol Gastroenterol Hepatol 12(1):354377 Han J, Li E, Chen L, Zhang Y, Wei F, Liu J, Deng H, Wang Y (2015) The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1

org/10.3390/molecules24183251 Bloomer, R