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This is a common pattern in hormone medicine: the evidence base precedes the regulatory framework, and physicians use clinical judgment informed by published data

2005 Dec 9;2(2):38-44

Cenci, S

R., Bethea, N

Most commercial products target the 0.5 to 1 percent range

Thus, in children with Down syndrome no special changes in the anti-oxidant system seem to have been produced to compensate for the higher levels of reactive oxygen species